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Foundations of Science

The Rise of RNA: The Cellular Workhorse Behind a New Class of Next-Gen Therapies

The Rise of RNA: The Cellular Workhorse Behind a New Class of Next-Gen Therapies

The Rise of RNA: The Cellular Workhorse Behind...

In a new Get Science series, we’re exploring how recent insights into RNA’s role in a variety of biological processes are helping scientists develop promising scientific breathroughs that may lead to new medicines for diseases, such as cancer and autoimmune conditions. ...

Cachexia Insights: Helping Improve Quality of Life in Chronically Ill Patients

Cachexia Insights: Helping Improve Quality of Life in Chronically Ill Patients

Cachexia Insights: Helping Improve Quality of...

It’s an experience familiar to almost anyone with a family member or friend who has fought a terminal illness, such as cancer or heart failure. In the final stages of life, it can seem as though their loved one is wasting away. This dramatic loss of muscle and fat is caused by cachexia, a wasting...

Meet the Team: Homegrown Therapies Get Ready to Fight NASH

Meet the Team: Homegrown Therapies Get Ready to Fight NASH

Meet the Team: Homegrown Therapies Get Ready to...

One of the biggest public health problems of our time is likely soon to face off with a new wave of cutting-edge medicines. As non-alcoholic steatohepatitis (NASH), a severe form of non-alcoholic fatty liver disease, or NAFLD, continues to be a growing public health threat, scientists are racing...

How Next-Generation Sequencing Is Helping to Build Better Vaccines

How Next-Generation Sequencing Is Helping to Build Better Vaccines

How Next-Generation Sequencing Is Helping to...

If you’ve ever tried an at-home genetic testing kit, you’re familiar with whole-genome sequencing, the technology that allows people to quickly and easily map their DNA. This same technology is now being used to track the genomes of potentially deadly microbes. ...

Capturing the Itch: Using Digital Wearable Devices to Help Patients with Atopic Dermatitis

Capturing the Itch: Using Digital Wearable Devices to Help Patients with Atopic Dermatitis

Capturing the Itch: Using Digital Wearable...

For people who have atopic dermatitis (AD) — an autoimmune condition that causes painful, itchy, and inflamed skin — symptoms often flare up at night, leading to disrupted sleep. Until recently, there hasn’t been a way to truly capture how much a person’s quality of life is impacted by these...

Designing Medicines to Go Where They're Needed: Lessons from Liver Targeting

Designing Medicines to Go Where They're Needed: Lessons from Liver Targeting

Designing Medicines to Go Where They're Needed:...

Designing transformational medicines for patients requires them to be efficacious and safe.  Sometimes, drug molecules have the desired effect in the organ of treatment and undesired effects in other organs, meaning one way to achieve a safer medicine is through directing the drug molecule to the...

Breaking the Rules of Biology to Beat Rare Genetic Diseases

Breaking the Rules of Biology to Beat Rare Genetic Diseases

Breaking the Rules of Biology to Beat Rare...

Like a skipping record, our genetic code has thousands of regions known as microsatellites where short combinations of base pairs — adenine (A), cytosine (C), guanine (G), and thymine (T) — repeat. For the most part, these repetitions are harmless. But in recent years, scientists have made...

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