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Impacts of Innovation

In Conversation with the Data Hippie: Using Real World Evidence for Better Medicines

In Conversation with the Data Hippie: Using Real World Evidence for Better Medicines

In Conversation with the Data Hippie: Using...

Despite having the Twitter handle @DataHippie, you won’t find Chris Boone in a tie-dye T-shirt proclaiming the merits of free love.  ...

Matching Drugs to Diseases: Advances in Targeting JAKs Leading to New Autoimmune Therapies

Matching Drugs to Diseases: Advances in Targeting JAKs Leading to New Autoimmune Therapies

Matching Drugs to Diseases: Advances in...

Janus kinases (JAKs) named after Janus, the Roman two-faced god of duality, are enzymes with two “faces,” or domains, that play a key role in signal transduction of cytokines, the molecular messengers that trigger the inflammatory and immune responses. Scientific discoveries related to JAKs...

A Drug Safety Scientist Inspired by the Migrant Farmers of California

A Drug Safety Scientist Inspired by the Migrant Farmers of California

A Drug Safety Scientist Inspired by the Migrant...

Sometimes it only takes one inspiring educator to set you on your career path. As an undergrad at UC Davis in the late 1970s, Jon Cook had a charismatic professor who sparked his interest in the field of toxicology, which studies the safety effects of drugs and chemicals on living organisms. ...

What an Artificial Eating Machine Can Teach Us About Medications

What an Artificial Eating Machine Can Teach Us About Medications

What an Artificial Eating Machine Can Teach Us...

The old saying “you are what you eat” may not be strictly accurate, but like many a timeworn adage, it holds a kernel of truth. For example, while eating a high-fat diet may not necessarily make people fat, the amount and type of fat in their diets still influences their overall health. When...

How Does It Feel to Have Sickle-Cell Disease?: When Listening to Patients Gives Researchers Clues

How Does It Feel to Have Sickle-Cell Disease?: When Listening to Patients Gives Researchers Clues

How Does It Feel to Have Sickle-Cell Disease?:...

Molecular biologists certainly have the insider’s view of a disease. They know (or try to find out) how it operates in the body on a cellular level. But the mechanisms of a particular condition aren’t the only thing that matters to these scientists. Starting “outside,” say by learning more about...

In Search of a Better Biomarker: Why Studying Liver Enzymes Matters for Drug Safety

In Search of a Better Biomarker: Why Studying Liver Enzymes Matters for Drug Safety

In Search of a Better Biomarker: Why Studying...

If you’ve ever had a liver function test as part of an annual physical, you may know that the exam screens for certain biomarkers, like liver enzymes in the blood. If these substances are found to be elevated, it may mean that you have a liver disease or have been exposed to some medications or...

Scientist Embraces the ‘Ick’ Factor to Develop a New Tool Against a Dangerous Pathogen

Scientist Embraces the ‘Ick’ Factor to Develop a New Tool Against a Dangerous Pathogen

Scientist Embraces the ‘Ick’ Factor to Develop...

Developing a vaccine to prevent the devastating disease caused by Clostridium difficile requires a reliable and sensitive test to diagnose the dangerous disease causing toxins produced by C. diff — and it also required scientists to figure out how to detect the toxins in stool...

Brenda Carrillo-Conde: Unlocking the Power of Connections

Brenda Carrillo-Conde: Unlocking the Power of Connections

Brenda Carrillo-Conde: Unlocking the Power of...

Brenda Carrillo-Conde has a talent for conjugation: making connections for the greater good — inside the lab and out. As a principal scientist with Pfizer’s Conjugation and Polytide Process Development Group in St. Louis, Missouri, she spends her workdays using chemical conjugation to...

Banking on the British Exome

Banking on the British Exome

Banking on the British Exome

The vast UK Biobank is a treasure trove of genetic data. Scientists are mining it now for potential therapeutic gems.  ...

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