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Impacts of Innovation

This Scientist's Life: Derek Buhl

This Scientist's Life: Derek Buhl

This Scientist's Life: Derek Buhl

Derek Buhl, Principal Scientist and project leader developing Central Nervous System drugs, began his career working with autistic children, even learning sign language to communicate with an autistic boy who was also deaf.

Flashback:  The First ECG

Flashback: The First ECG

Flashback: The First ECG

Willem Einthoven found the beat and built a machine that could measure the electrical current a heart creates. It weighed 600 pounds. An electrocardiogram — called informally an ECG or EKG — measures the small electric waves that a human heart creates. It’s been doing it for more than a century....

3-D Molecules Move into the Fast Lane

3-D Molecules Move into the Fast Lane

3-D Molecules Move into the Fast Lane

Thanks to computational and structural biology, we can create 3-D models of the biological “locks” and “keys” that may lead to breakthrough medicines.

This Scientist's Life: Morrie Birnbaum

This Scientist's Life: Morrie Birnbaum

This Scientist's Life: Morrie Birnbaum

Morris Birnbaum and his group are responsible for discovering the molecules and pathways that a new drug should target, as well as the clinical trials that give the first signs of evidence that a potential medicine works in the way it’s intended to.

 How Human 'Gene Knockouts' Are Pointing the Way to New Medicines

How Human 'Gene Knockouts' Are Pointing the Way to New Medicines

How Human 'Gene Knockouts' Are Pointing the...

Some people are naturally missing the working copy of a gene, the result of which can range from no effect at all to, occasionally, profound effects, such as very low cholesterol or congenital insensitivity to pain. Such significant, unusual medical characteristics are commonly referred to as ...

Tapping Coding Virtuosos to Solve Research Challenges

Tapping Coding Virtuosos to Solve Research Challenges

Tapping Coding Virtuosos to Solve Research...

Medical researchers turn to crowdsourcing in the coding community to crack DNA data challenges. 

This Scientist's Life: David Gray

This Scientist's Life: David Gray

This Scientist's Life: David Gray

David Gray, a Senior Director in Pfizer’s Neuroscience Research Unit at Kendall Square, Cambridge, and expert in medicinal chemistry, is leading a team developing a potential first-in-class Parkinson’s disease treatment.

Consumer DNA Kits Give Research a Boost

Consumer DNA Kits Give Research a Boost

Consumer DNA Kits Give Research a Boost

Patients with lupus and inflammatory bowel disease (IBD) recently became a pivotal part of studies without ever stepping foot in a clinic or hospital, thanks to a collaboration formed between Pfizer and the genetic testing company 23andMe. The mission: find genetic clues that may someday lead to...

6 Views of a Neuron by Golgi and Cajal

6 Views of a Neuron by Golgi and Cajal

6 Views of a Neuron by Golgi and Cajal

Camillo Golgi and Santiago Ramón y Cajal stain cells and uncover the intricate secrets of the nervous system.

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